The discovery was made when this mussel was involved in a research programme looking at marine molluscs ( shellfish ) to see if any of them contained a possible treatment for cancer. The Green-Lipped Mussel ( GLM ) was included in this programme because it is unique and is only found in New Zealand waters. Nothing was found in the mussel which would help with cancer but the trials indicated that the GLM demonstrated significant anti-inflammatory activity and anti-inflammatory drugs are used to treat arthritis. Thus it was thought that an extract of the Green-Lipped Mussel ( GLME ) might provide a valuable, natural anti-arthritic treatment for this very serious disease. We now have over 25 years of dedicated research which, together with the experience of arthritis sufferers worldwide, has proved GLME to be a highly successful treatment with the added bonus of not exhibiting the classical adverse side effects associated with anti-inflammatory drugs.

GLME, has been shown in laboratory and clinical trials, treating both human and animal subjects, to be very effective in treating both the rheumatoid and osteo forms of arthritis. How it does so is an interesting story ( involving the use of a few medical and scientific terms which I will try to explain clearly ) and is one of the indications of the powers of nature, in particular that occurring in our seas, to provide remedies for most ailments. The difficult part is finding these remedies amongst the multitude of life forms present in the seas!

GLME has two distinct anti-inflammatory activities naturally present. The principal anti-inflammatory activity is due to a carbohydrate complex which has the ability to inhibit the emigration of neutrophils from the blood vessels. What this means in everyday terms is that soldier cells ( neutrophils ) are inhibited from attacking our own cells when an inflammatory stimulus is present. This is an oversimplified explanation of neutrophil action but, hopefully explains why the inhibition of this activity helps to reduce inflammation. This same mechanism is performed by some anti-inflammatory drugs.

The second anti-inflammatory activity is due to the effect of the natural content of some long chain fatty acids on cyclo-oxygenase activities. These cyclo-oxygenase ( COX ) compounds are enzymes which the body uses to biosynthesise chemicals called prostaglandins . There are two forms of these COX enzymes. COX 1 is constitutive and a natural component of normal tissue. It performs important functions in our body. The other form ( COX 2 ) is induced when an inflammatory state, such as arthritis, is present and it produces pro-inflammatory prostaglandins. It is therefore desirable to inhibit this enzymic activity.

Anti-inflammatory drugs such as Aspirin, Indomethacin and Phenylbutazone perform this function effectively but, unfortunately, they inhibit both COX 1 and COX 2 activities thus inhibiting the production of the prostaglandins which are needed for the protection of the stomach lining, helping kidney function and also some blood characteristics. GLME has the very desirable, and most important benefit, of inhibiting just the COX 2 activity which produces the damaging prostaglandins whilst not influencing the necessary ones.

Another valuable feature of the product is that it has been found to have natural gastro-protective properties. This means that, not only does it not damage the delicate stomach lining, it actually provides a protective function for it. Thus the product is able to relieve the inflammatory symptoms associated with arthritic diseases whilst protecting the stomach from the damaging effect of some pain killers should a person need to be taking these at the same time.

This was a question which puzzled us for some time. We were well aware of the product's success in treating osteo arthritis but could not offer an adequate explanation for this success. However, the discovery of the activity of the chondro-protective activity of glucosamines and chondroitin sulphates led to the answer to our puzzle. GLME has a natural content of glycosaminoglycans and this is the name for a group of polysaccharides which includes chondroitin sulphate amongst a few others such as dermatan sulphate, hyaluronic acid etc. These glycosaminoglycans ( which use glucosamine molecules as the raw material for their building blocks ) are used by the body for the biosynthesis of compounds called proteoglycans. The proteoglycans have a very strong affinity for water molecules in the joints, to which they bind, and form very large, slippery, space filling molecules. The function of these large combination molecules is to act as shock absorbers and also lubricants in the joints. We have therefore, in GLME, anti-inflammatory activity which is necessary to relieve the inflammatory component of osteo arthritis coupled with chondro-protective activity which relieves the physical problem of degenerative joint condition ( osteo arthritis ).

There is one further point which is worthy of mention here and this relates to the increased rate of cartilage degeneration in the joints in arthritic disease and also in advanced age. In young people and those not affected by arthritis, the rate of cartilage degeneration in the joints is equaled by that of regeneration. In the older person and in arthritic disease states this balance is upset leading to a reduction in the padding and lubrication of the joints. Certain cytokine induced enzyme activity is known to accelerate the breakdown of cartilage process and the inhibition of this enzymic activity is thus very desirable. GLME has been shown in laboratory studies to inhibit cytokine activity which would lead to the production of cells responsible for this process.

Not necessarily, some people find that, once they are experiencing a satisfactory level of relief, they can stop taking the product altogether until another flare up occurs. However, the majority of people prefer to gradually reduce the daily usage, by trial and error, until they establish the minimum daily maintenance requirement, usually one or two capsules. There are, of course, some cases where it seems to be necessary to continue the full usage all the time but these would certainly be a minority.

I suspect that, in many instances it is a fear of the symptoms recurring, after being free of them, that makes people reluctant to cease taking any capsules at all. Since taking them on a continual basis will not do any harm this is a quite acceptable practice. There could even be some prophylactic benefit in relation to the inhibition of degenerative joint disease but I don't know if this is the case yet.

The normal level is based on about 1 gram of the extract powder per day for the average adult. This equates to 2 capsules of the 500mg each day capsules each day but there is no danger in doubling this level if desired. There have been occasions where doubling the level has achieved results which were not apparent at the recommended level but this has not been a general finding.

Certainly not ! In fact I do not believe that there is anything which has pharmacological activity which may not have some side effects. The question is then, the nature and level of side effects which might be experienced.

The side effects which might be experienced by people using Seatone GLME are based on the clinical trial reports plus those reported by customers during the 26 years of worldwide usage. There are no serious adverse side effects associated with use of Seatone GLME. However, because the product is a shellfish derivative, it may create an allergy reaction in people susceptible to shellfish allergy. If a person wishes to try the product but suspects that they may be allergic to shellfish, they can just take one capsule per day for a few days and , if no allergy reaction occurs, they can then increase gradually. If a person does experience an allergy reaction they should stop using the product and the symptoms will disappear. A reduction of the allergy symptoms can be accelerated by use of a suitable anti-histamine prescribed by a medical practitioner.

In a few cases, there has been a temporary exacerbation of arthritic symptoms shortly after commencing to use the capsules. This condition has only lasted for a few days and has almost always preceded excellent results.

Some people have experienced mild indigestion and flatulence but the likelihood of these can be minimised by making sure that the product is consumed at the start of a meal.

On the positive side, there is one beneficial side effect which has been reported frequently by humans and is very noticeable in animals. This is a significant enhancement of vitality, often described as 'a feeling of well being'. This could, of course, be simply due to the effect of relief from pain coupled with increased freedom of movement.

Incidentally I should advise that, even though GLME is derived from a widely consumed food, the product has been subjected to the standard, international tests for toxicity and also teratogenicity to ensure that it is perfectly safe to consume at many times the recommended usage level without causing toxic effects or adversely influencing a developing foetus in a pregnant person.

There have been no reports of any contra-indications when Seatone GLME has been taken together with other anti-inflammatory products whether these have been drugs or natural preparations. It is unlikely that Seatone would contra-indicate with other pharmaceuticals due to its basic food status. However, it would be preferable for it not to be used if a person was using monoamine oxidase inhibitory drugs ( anti-depressants which are now not generally used ).

Also, it is important to note that Seatoneshould not be used to treat gouty arthritis. The reason for this is that gout is caused by an excess of uric acid which precipitates in the joints. In common with cheese and wine shellfish contain a significant level of purine nitrogen which would act as a precursor for the biosynthesis of uric acid!

The mussels are not taken from the natural beds, they are cultivated on marine farms. In fact, instead of pillaging the seas we are farming the seas to produce a valuable medicinal product ! The marine farms are very strictly controlled by the New Zealand government and our regulations are such that we can trace an individual GLME capsule right back to the time of day and the specific farm from which the mussels used to make that capsule were harvested.

The mussels are grown on special ropes which hang down from horizontal lines at the surface. The horizontal lines are supported by buoys at each end and other buoys are added at intervals along their length as the mussels grow and increase the weight on the lines. They are usually harvested after about 18 months from being seeded. No fertilizers or herbicidal type agents are involved in this farming as it merely optimises the natural properties of the sea water column by having the shellfish suspended vertically instead of horizontally on the sea bed.

We are very fortunate in New Zealand in having , clean, unpolluted coastal waters which are highly productive and of an excellent temperature range for a variety of species.

Yes, this is true. However, New Zealand has the best monitoring programme for potential blooms of these algae in the world. All farming sites are monitored on a regular basis and the regulatory authority will prohibit the harvesting of any shellfish from any farms within a suspect area. This programme, in addition to the other monitoring and quality assurance programmes carried out by governmental regulatory authorities ensures that New Zealand shellfish are perfectly safe.

No, unfortunately there are several ' imitation' products which will not have the beneficial properties I have described for reasons which I will explain. This is a very important question because people could be spending their money and hoping for relief from one of these products which has no therapeutic value whatsoever! The customer is, unfortunately, not able to tell by the appearance, smell or even the nutritional analysis whether the product is the genuine extract or simply freeze dried ( lyophilised ) whole mussel meats ground into a powder. The only way the customer can be sure that they are getting the genuine product is by requesting it by the brand name.

The reason that these imitation products , which are basically just freeze dried whole mussel powder, do not perform the functions I have described for GLME is that the anti-inflammatory activity of the mussel dies off at a rapid rate when the mussel dies and also if the extract is not stabilised during the extraction process. Thus, because mussel powders ( as opposed to mussel extract powder) are made from frozen mussel meat, in some cases, even from cooked mussel meat, and the activity has been lost or destroyed. This fact does not show up in a nutritional analysis but has to be established by a special bio-assay which has been specifically developed for proving that production batches of GLME have an acceptable level of activity. There is one other mussel product which is currently being marketed which is an extract. However, it is only the lipid ( oils and fats ) fraction of the mussel which have been solvent extracted and presented in soft gelatin capsule form. Whilst this product will have some of the activity which I have described for GLME, it is only one of the active fractions which are present in GLME and therefore much less effective than the complete extract.

I feel very strongly, that people suffering painful conditions such as arthritis, should not be misled into paying for products which will only lead to false hope and eventual disappointment which is why I am happy to answer this question in such detail.

One of the reasons that I have been able to give the information in response to your earlier question with confidence is that the product has been subjected to a number of randomized, double blind clinical trials involving both human and animal subjects. These trials have taken place in hospitals and research centres in several countries which have included, the USA, United Kingdom, France, Japan, and New Zealand. I have a summary of all the references to this, and other , research most of which has been published in reputable, peer reviewed journals, which I am happy to provide to anyone who wishes to question any of my statements.

Basically the results of the clinical studies have confirmed the evidence received in numerous, unsolicited, anecdotal reports from people all over the world. Many of these reports have come from countries where the product is not on the market but has been sent there by relatives in other countries who have already had experience with it.

Generalizing, both the anecdotal and controlled clinical study results indicate a success rate of about 68% for rheumatoid arthritis and 85% for the osteo form in human subjects. It is only fair to point out that these success rates are not better than can be achieved with regular drug therapy. However, the big advantage of the GLME treatment is that none of the classical adverse side effects of drug therapy will be experienced. Also the product can be taken continuously on a long term basis ( I have personal experience with my mother who has taken it for 18years ) with no ill effects.

The level of success described by human subjects, success being a matter of degree, has been surprising. It has ranged from those who have just been able to open a jar or hold a pen again through professional surgeons who have been able to resume operating practices, musicians who have resumed playing piano at concerts to wheelchair bound subjects who have been able to resume a more normal mobility. Because of the beneficial influence noted by athletes ( subsequently demonstrated in a double blind clinical trial on athletes ) some football teams now issue the product to the team as routine to minimise joint or connective tissue damage and to reduce injury time away from the field!

These are just a few examples of the range of subjects which have responded favourably to treatment with GLME. The importance of this evidence for me is that it removes the suggestion of a placebo effect being responsible for the results. This is a common suggestion which is made when good results are described by human subjects. I firmly believe that the combination of this evidence, together with that from the independent clinical trials in humans and in animals, is sufficient to prove the value of this marine natural product as a safe and effective treatment for one of the world's most debilitating diseases.